CEESDEKKER.NET SECRETS

ceesdekker.net Secrets

ceesdekker.net Secrets

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Halfway by his profession, Cees Dekker reinvented himself. Just after a long time of hardcore physics, he shifted his aim to ‘nanobiology’ on the transform in the millennium. A time period he coined himself, as being a subject of reality.

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‘It had been merely a matter of finding up a ebook on cell biology and beginning to read through. I had originate from a entire world of ultra-superior vacuums, cryostats and quantum phenomena, and now I used to be Operating at home temperature with molecular biology kits.

Sculpting nano-electrodes with a transmission electron beam for electrical and geometrical characterization of nanoparticles.

This yielded a breakthrough. Inside only some months, we had been able to measure transportation by means of somebody solitary-walled carbon nanotube. Dependant on minimal-temperature experiments by a superb PhD college student in my team, Sander Tans (now a valued colleague and professor at Delft University of Know-how with the Energetic research lab at AMOLF in Amsterdam), we showed that carbon nanotubes were authentic quantum wires with very prolonged (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.

Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes

‘At the beginning we looked at biological devices with a physical look at and acted on The premise of the equipment we understood. It took a number of years prior to we started out Performing more on the big biological troubles. I then began to connect with it nanobiology, a term that did not exist at time.

Nanopores signify an elegant and versatile tool to measure single molecules. We exploration novel detection modes with good-point out nanopores together with several solutions to evaluate proteins with nanopores. Assignments encompass the next:

‘You shouldn't just give thought to the thoughts of tomorrow, but will also consider the questions of the working day just after tomorrow’

‘The fantastically refined way where aspects in character function never ceases to amaze me. If we address the puzzle of how lifetime came into becoming, I expect that my amazement for the complexity of development can have elevated and with it my awe with the greatness on the Creator.’

Considering that 2000 he moved to single-molecule biophysics and nanobiology, with investigate from reports of DNA loop extrusion and supercoiling to DNA translocation via nanopores. Extra just lately his study has centered on learning chromatin composition and cell division with microbes on chip, even though he is also aiming to ultimately Make synthetic cells from the bottom up.

Cees Dekker is Distinguished University Professor at TU Delft. Skilled being a physicist, he pioneered nanotechnology with a lot of discoveries on carbon nanotubes from the nineties. Considering that 2000, he moved to solitary-molecule biophysics and nanobiology. His latest research focuses on (i) nanopores for protein sequencing; (ii) chromosome composition, especially SMC motor protein; and (iii) creating a residing artificial mobile from lifeless molecules. Dekker can be an elected member of the KNAW and fellow to the APS and the IOP.

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Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim on the pore is highlighted in https://www.ceesdekker.net red, plus a 3D rendering from the movement of the DNA rod is shown.

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